They are the most thermodynamically stable structure that polypeptides can form, and require constant housekeeping to prevent. Accumulation of amyloids is like failing to taking out the trash in your house.
Afaik, there has never been a disease state checked for amyloids that failed to be associated with them (heart disease, cancer, stroke, etc).
>"From a wide range of in vitro experiments on peptides and proteins we now know that the formation of amyloid structures is not a rare phenomenon associated with a small number of diseases but rather that it reflects a well-defined structural form of the protein that is an alternative to the native state — a form that may in principle be adopted by many, if not all, polypeptide sequences
These observations, therefore, have led to the remarkable conclusion that, at the concentrations present in living systems, the native states may not always represent the absolute free energy minima of the corresponding polypeptide chains — the native form of a protein could in some cases simply be a metastable monomeric (or functionally oligomeric) state that is separated from its polymeric amyloid form by high kinetic barriers" http://www.ncbi.nlm.nih.gov/pubmed/24854788
I've previously commented the same thing:
In practice you have to figure out a way to detect them non-destructively (eg via light interacting with it in the tissue or some metabolite in excretions).
If you have any examples of these "uninformed scientists" on display it may be helpful to others. The purpose is not to point fingers, but to see where things may have gone wrong.
Just like sneezing/coughing does occur normally, but is also a symptom of many different health issues, and in the worst cases could lead to broken ribs, etc.