I've noticed bugs such as the new tab button stops working (command-t still works though), child tabs not being promoted to top-level tabs when their parent is closed and a few other strange cases of tree state corruption. Particularly it sometimes happens when dragging tabs around to reparent them, although I haven't been able to nail down any concrete rhyme or reason to it. My other extensions are umatrix, ublock origin and tampermonkey, I don't think there is any strange extension interaction going on.
Despite all of this, TST is still too useful to not use.
Have you tried submitting a bug report to the author of TST maybe they don't have a mac and could use more feedback.