He was later involved  in a case of research fraud involving resveratrol.
Snake oil I would say.
This is beyond "guilt by association" it's "guilt by non-association."
And Dr. Sinclair cited Dipak Das in his research and knew him personally, when they both served together on the scientific committee of the “first international scientific conference of Resveratrol and Health” in Denmark in 2010
Well, I would speculate that it would require a multiphase treatment to anything like youth restoral. At the same time, I think ultimately we simply don't know. Human evolution didn't necessarily select for or against humans living indefinitely and there may fairly simple mechanism whose interruption could add X many years to human span - or there might not be.
Well, on the one-hand, the article goes on to show Sinclair did know Das, on the other hand, the article doesn't show any close connection. Moreover, the article asks "How peripheral was Das' research?" and apparently answer "well, I guess it was kind of peripheral".
The Lowe links go to spam so it's hard to figure out some of the implications too.
Individuals may love agelessness, but let's not kid ourselves that it's anything but a disaster for species, society, etc.
More concretely, evolutionary pressure for immortality is nil when reproduction (including evolution itself!) is a more efficient way to spread and preserve genetic material.
If anything, aging + death would be the evolved trait to ensure smoother adaptation!
You're right, however to me what seems worse path to take evolutionarily is to choose to destroy accumulation of experiences and knowledge by not passing it to next generation and instead starting with the first rudimentary step of half DNA crossing combined with random mutation.
Though we have developed ways (books) to pass that knowledge to next generation in place of nature, experiences are still lost.
It seems like evolution is more focused on the survival than survival of the fittest.
If that stops being the case it will lead to more political action. And potentially more force. Not sure if that’s good or bad for society.
Things might have more stability, but change and opportunity would hardly exist and each succeeding generation would be permanent underclasses of children.
"A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it. " - Max Planck
My assumption is historical learning is valuable up until some percentage of your memories are false and/or obsolete. Even in a perfectly healthy individual both happen continuously.
At some point an empty vessel has more utility than a trained up individual. So some heuristic that arbitrarily purges old people and their ideas is adaptive.
However, it isn't a compelling reason for the sizable expense of developing this outgrowth of sirtuin / calorie restriction research. That funding and person-years of researcher time could have gone towards far more effective programs such as senolytic development, or other SENS damage repair approaches to aging.
Not all NAD+ precursors are the same. The evidence in animal studies suggests that some (such as nicotinamide ) do basically nothing. The most effective approaches appear to be infusions, but they are not cheap.
Currently nicotinamide riboside is produced by one company in the US, and the retail price reflects that. If you do decide to take it for the long term at the dosage from the studies of 1g/day or so, it is considerably cheaper to order by the kilogram from Chinese manufacturers (plenty of manufacturers on Alibaba) and run the necessary mass spectrometry and other tests per batch to ensure quality (plenty of providers on Science Exchange).
While you are taking it, consider that this is small potatoes. It is a tiny effect in the grand scheme of things. Exercise has a larger and more reliable outcome. The research community should be doing better than this (and is in the case of senolytics) and people outside the research community need to become better at telling the difference between marginal and useful approaches to the challenge of aging.
As someone with a background in supply chain security and fraud please DO NOT put anything purchased from China in your body without thorough testing.
So all that caution that most people feel regarding Chinese manufacturers should be spread out a little more and applied to those closer to home as well.
The show notes on the episodes are always really good, and you can almost read them without listening to the episode.
This lapse is unfortunately way too common and puts the author as well as the publisher in an unprofessional light.
Presumably, this is the paper:
Given the title, you can look up on Google Scholar:
Click on the "Cited by" link at the bottom of the entry to see the 47 papers that have cited this one to date:
Reverse chronological sort didn't find anything that looked like a follow-up.
"A comprehensive concept that connects NAD+ metabolism to the control of aging and longevity in mammals has been proposed, and the stage is now set to test whether these exciting preclinical results can be translated to improve human health."
My google search also resulted in: https://medicalxpress.com/news/2016-12-pathway-linked-slower...
TLDR; NAD+ over-activeness is associated with a deadly form of brain cancer, and the article ends with an open question from an expert if it could be modulated to not have this adverse effect.
The next step is probably figuring out the tricky balance between these two ends.
Asking because I already get too much vitamin b3, 6 and 12 from energy drinks.
Here is a study on adult humans:
Edit: Comment edited.
But it is around $50/month so I'm not sure if I will continue to take it forever. Elysium is mostly a marketing company, so hopefully they will have competition and the price will drop if more research proves NAD's effectiveness when taken by humans long-term.
What could you have noticed?
What results are you seeing?
This was literally after ~1-2 years of 0 growth, and not much has changed aside from that in terms of my diet and exercise routine.
All it proves is that through actual biological processes or through placebo effect it has an effect on OP.
- Having low NAD+ leads to all sorts of terrible, horrible, no good, very bad issues. 
- You need NAD+ for muscle and energy. 
Maybe "the low NAD+ levels" are a symptom, not a cause, since its linked to unrelated diseases?