I do not think it would be foolish to use it with Vue and Reason is actively used with Node. For instance:
There is a lot of work going into the backend for Reason and I'm pretty excited about this.
You may want to look into this project which is an alternative to the React ecosystem: an implementation of the Elm architecture in OCaml/BuckleScript (and thus Reason).
> What about server-side with Node?
Possible with Reason, yet compilation to native is also possible from Reason... This allows one to use really fast all-OCaml libraries. Like this HTTP server: