Absolutely. I will never buy a keyboard with an attached numpad because it splays my mousing hand way out to the right in an very awkward manner. That is one of the reasons I bought the UHK.
One of the really cool features of the UHK I was surprised to discover after I received it is that it can control your mouse cursor and right/left/middle buttons by using the Mod keys and h/j/k/l keys. Yes, I'm sure you can download some utility that enables this on any keyboard but it's nice to have it built into the firmware.