nohup /usr/lib/firefox-esr/firefox-esr \
-P Facebook \
1>/dev/null 2>&1 \
I also have a similar version which just copies an empty profile to a random folder in /tmp and then uses that freshly separated from everything else.
This seems like a complicated process, but it's trivial to add more in later and I can basically have as many as I want. I did it as a bit of an experiment to see if something like this feasible (not technically, but more socially). I.e. will I get lazy and stop using it soon. So far it's pretty easy and is a nice way to take webapps and basically devote a firefox profile to it in a way that makes it seem almost like an electron app, but without all the extra useless stuff.
Tldr: I do something similar except I only use Firefox and it's profiles.
edit: Also should say I run debian with cinammon desktop so this probably won't work for most people here, but something similar is probably possible on every system.