Actually, that applies to pretty much all roads—not just highways.
I also think the shifts coming in transportation will be a lot more than an "automated uber". There will likely be a lot of automated carpooling and carpool discovery along the line of ad-hoc ride-sharing discovery. Bottom-line, I assume there will be a lot less parked hunks of metal in city centers, which will itself alter what an efficient layout entails.
The entire US is designed around personal automobile ownership to an incredible degree. Anything that affects that one way or another drastically changes optimal design layout for both residential and commercial planning.
As a simple example of this, if you've ever driven down a corridor of highway or an arterial route that is one strip mall after another behind parking lots, imagine how that changes is a large chunk of people are no longer driving their own cars leisurely, but instead hiring transport to a specific point. Road visibility is much less important. Parking lots in front are mostly superfluous. Basically, walk-able downtown areas and enclosed malls may see (and I think already are seeing) a resurgence.