Additionally, please note that this drug has already been approved in the US, since May.
Now, onto the meat of this. If I'm not mistaken, erenumab is a cgrp inhibitor that made much fanfare a few months ago in New England Journal of Medicine when two studies found a clinical benefit in cgrp.
Basically healthcare providers are prescribing this if you failed the aforementioned therapies for migraine prophylaxis (since those are way cheaper).
On a funnier note, medical students such as myself have started referring to all of these new biologic drugs as "what-the-f*-umabs" since they all have weird names and we can't keep up with the rapid development of them.
I'm currently taking Cosentyx and it's been life-changing.
More and more the treatment goal of my condition is becoming sustained drug-induced remission.
On the other hand, however, you then run into rapidly increasing costs for medication, which isn't going to be sustainable in the long run. Maybe the economies of scale will bring that cost down, but I'm no expert on that.
They have similar name endings because of naming conventions. umab indicates a human monoclonal antibody. See https://en.wikipedia.org/wiki/Nomenclature_of_monoclonal_ant..., https://en.wikipedia.org/wiki/Drug_nomenclature#List_of_drug...
"These patients are in a desperate and vulnerable situation, and illicit psychoactive substances are often considered a last resort. There appeared to be little or no interest in psychoactive effects per se as these were rather tolerated or avoided by using sub-psychoactive doses. Primarily, psilocybin, lysergic acid diethylamide, and related psychedelic tryptamines were reportedly effective for both prophylactic and acute treatment of cluster headache and migraines. Treatment results with cannabis were more unpredictable. No severe adverse events were reported, but it was observed how desperation sometimes spurred risky behavior when obtaining and testing various treatment alternatives." 
"The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headache may be warranted."
Really wish it was legal to research around this compounds - the case of 2-Bromo-LSD suggests a successful anti-migraine drug does not have to have psychedelic effects.
Frequency is what chronic migranes are about.
I used to get at least one a week, and I know there are people who get them much more often. I'm glad there are advances being made in this area because I feel like for all the pain migraines have caused me, I'm mostly a dabbler and others have it much worse.
It's really one of the worst pains I've ever experienced. They are kind of evil. With some pain, you know "at least it's for a reason" (like your body self-healing something). With migraines, it's devoid of any purpose. The pain only exists to torture you. Nasty things.
Everyone is different, and there is so much we don't understand about migraines (and clusters, which often benefit from migraine research). If you think that ginger, cannabis, or just avoiding your triggers is all it takes, that's not always (nor probably often) the case.
I hesitate to subject a friend's personal blog to the HN effect, but if you want to learn about chronic migraine from one firsthand account, read through some of the archives at thedailyheadache.com. She has been trying desperately and relentlessly to find peace for a long time.
I always have a supply of MaxAlt (rizatriptan benzoate) with me which short circuits my migraines if I take it in the correct window of time. 1 MaxAlt usually works, 2 or 3 in the worse case.
A low carb diet, or ketogenic diet, can cause lowered blood pressure. The only downside with diet instead of medication is that eating carbohydrates will reverse the effect.
Is there any way to find out how much of the R&D money for the medicine came from public funding? I can understand if the information is simply not available because it comes from a larger pool of R&D monies.
> Erenumab is now expected to be considered by English and Scottish health agencies to assess whether it is appropriate for NHS use.
Curious whether it has to be approved by the EU first before its use by NHS is allowed (or if its assessment is even worth it until EU approval occurs). Also curious whether "appropriate for NHS use" means at no cost to migraine sufferers.
What if something common like changes in atmospheric pressure trigger it? What if you have multiple common triggers? What if you don't know all your triggers?
Then you can hook up all the data into a recurrent neural network that finds the patterns in the data and lets you know what combination of conditions will give you migraines.
It's really easy to find all your migraine triggers if you follow these very basic steps.
This is my experience too. I know a good number of my migraine triggers, but some days I do everything right: I eat good food (regularly), plenty of sleep, no over-exertion, lots of water, breaks from screen time, no eye strain, etc etc...still get a fucking migraine!
Sometimes there's just not a reason for it.
Also, might be helpful to just download your consciousness into a synthetic brain
Honestly, I've long dismissed the claimed benefits of ketogenic diets like 'reduced inflamation' as... minor and uninteresting. A few weeks into a low-carb diet for my migraines and my sedentary butt is suddenly running and with my untrained knees never having felt better. I would not be shocked if there were other beneficial effects of ketosis on migraines.
Preventive migraine treatments are not painkillers (beta blockers, anti-epileptics, and more, among which the CGRP blocker described in the article).
2. It depends on what is causing your migraines. I have a family member that will smoke occasionally if the migraines get bad enough. But they also have allergies, and sometimes smoking irritates them. That means that she has a small chance of the headache changing forms. One type of pain traded for another.
3. The situation is pretty horrible. I don't have them, but they run in my family. I've had to pick a person up because they got an aura while driving. I've known another that goes literally months with headaches. The pain gets bad enough that folks near "If I overdose, at least the pain stops". It can literally disable folks for hours. Cannabis doesn't always work well enough and doesn't prevent them. Most things that help with the pain still disable folks enough that they can't drive nor do their work.
2. You don't have to smoke it.
3. It doesn't work for all, but that is not an argument to deny it to those that they find it works for them.
2. Of course not. But that takes away from the ease of above: The person in question gets some irritant effects from the smoke, but also tends to get allergic reactions from random stuff... like corn pollen. The same person will try about anything legal.
3. I'm not argueing that at all. I'm actually very pro-legalisation, both for recreational use and for pharma use (not only with pot, but including drugs I wouldn't personally ingest). I generally push there to be separate categories for the uses, in part so we can specialize (I think this will happen). But I also try to push back at cure-all sorts of language, and this was more to demonstrate that even with it legal, migraines are still horrible and it doesn't prevent them. In a best-case scenario with this new medicine, a person would have the prevention available plus a variety of treatments to treat the ones they still get, including cannibus if it happens to be right for them.
I am skeptical of anecdote because half of my family is Mexican and the grandmothers on that side of the family are convinced that being cold causes colds or that homeopathy actually works. But in reality it’s just quite literally old wives tales not backed by any reputable, reproducible studies.
To be clear, I am not disputing that cannabis could have some beneficial effects, but the science should be there before we start suggesting that government is up to some conspiracy to boost pharma profits.
Am marijuana is still illegal in most EU countries — so don’t blame pharma for not manufacturing and testing cannabis medications, blame the democratically elected EU governments for trying to “protect” people from making their own decisions about what to ingest.