So, there was a statistically significant difference in brain activity between participants who drank cool water and participants who drank (hot?) tea with added L-theanine. Curious setting.
Never liked either
But also be careful about using too much of a ton of honey. Apparently the body will naturally purge an excess of honey ingested at once.
That's why you should first make your tea, wait till it cools off, and only then add honey.
As far as I know, honey has two material effects: it is tasty, and there are some studies suggesting it’s an effective cough suppressant. I’ve never heard of either one being temperature dependent.
I’ve heard people claim that local honey has anti-allergy properties. I would certainly believe that the active ingredients in pollen are destroyed at high temperatures. But AFAIK any purported benefits are entirely unsubstantiated, and the FDA notes that bee pollen can be actively dangerous to people who are allergic to the pollen.
P.S. I drink my tea above 44 C.
It's probably also what causes honey to have antibacterial properties when you put it on a wound.
That's not to say that it would have any effect on bacteria in your body if you eat it.
The enzyme is deactivated or denatured somewhere in the neighborhood of 50 C. 
Honey itself has antibacterial properties but there's no evidence I can find to show those properties translating to your body after you eat it. It makes sense that honey is effective to help treat wounds because it's still honey, not mixed up in your stomach and beyond. I'd bet stomach acid would do a fine job denaturing that enzyme as well, heat be damned. So maybe don't boil your honey if you're going to put it on a scrape, but drink your tea as you like. I personally really dislike honey in tea.
3. http://www.jbc.org/content/278/27/24324.full "The midpoint for thermal inactivation of residual activity and the dissociation of FAD was 59 °C"
That's a new one on me. Where did you hear that? What do you mean by purge? Vomit?
Eat too much anything and you will naturally purge.
Hot water, a large measure of Powers Whiskey, honey and a chunk of lemon with cloves pushed into the skin. Leave to steep for 6-7 mins, give it a stir.
Top notch for the alleviation of colds and, well, anything really :)
When Alice first drinks Grasshopper Tea
sorry, could not resist the quote :)
The research isn't bad, but the implied finding is. It should say "Hot water with tea flavouring and L-theanine has a measurably different effect on humans than cold water".
This paper will no doubt lead to a whole wave of dietary additives, fooling millions of people into thinking they're doing something with scientific basis.
What can the science community do about it?
Restrict papers without peer review? Require per-institution "scientific method" inspectors? Something else?
With typical dosing being 100mg caffeine:200 mg l-theanine
You can buy l-theanine pills and take it with coffee. If you'd like it from nature, Matcha has the highest L-theanine content. This is because L-theanine is an anti-oxidant made in the roots and sent to the leaves to prevent against damage from the sun. Matcha tea plants are kept in the shade for the last couple of months, so they build up the theanine and it is not used up. The full leaves are then ground up, but will only contain around 40 mg per serving, which is why I generally recommend supplementing it. Suntheanine has a patented form that is made in a biofermentation process that yields nearly 100% pure L-isomer theanine.
Also interesting is that, while L-theanine the molecule wasn't "discovered" until 1949, the Japanese ceremonial tea scale has been for hundreds of years, organized by increasing levels of theanine content.
I've tried other caffeine products and l-theanine alone, nothing had that great effect as Xenadrine did, I'm not sure if maybe one of the other ingredients is a nootropic either, could be, I imagine, or could just be the quantities.
Coffee and normal caffeine doesn't do much for attention/focus for me... but I drink way too much soda..or did.. (weaning off)... About to do keto for a few months.
I was aware of this already—thanks for bringing it up though, since I think it’s important that people be aware of it. Unfortunately I haven’t found an equally effective yet safer replacement for nausea & allergies. Ginger works pretty well, but iirc that’s because it’s also a mild anticholinergic/antihistamine.
Although the research in this area is very inconclusive afaik, it could even be placebo.
I would recommend avoiding anticholinergics!
So many of the supplements and nootropics
that I've tried for programming are the same way.
I especially love biking after having some, I get into a great flow state and can go much longer.
liver toxicity aside
That's what I was looking for. I recall a burst of interest/hype (choose your word), several years ago, about L-theanine. One company/salesman (the very prominent-looking, TV type, although I think this may have been via one of those suspicious-looking PBS specials ), was promoting it in a topical cream. Apparently, it would pass from that into the bloodstream.
There was little if any discussion in that... "pitch" about dosage limits. 'It sooths you. Rub it on. Rub on some more...'
I wondered. And more recently, I finally started seeing reporting of downsides -- although I didn't see much. Liver toxicity.
Like so many other drugs/supplements (choose your word), a lot of harm to reputation and perhaps also people is done, when no work or discussion is included about effective and safe dosage.
Like the "self-taught" herbalist my acupuncture friend had a (non-romantic) "thing" for, years ago. "Intuitively" brewing up pots of herbal tea for people, in his home. Not wanting to disappoint her, nor offend him, I drank some. And felt like crap for two days. Thank goodness my liver made it through unscathed.
I don't want the FDA shutting down everything on behalf of the pharmaceutical companies (who've played their significant roles in side-lining a lot of effective but unprofitable -- for them -- treatment). But I would welcome more intelligent conversation about and thoughtful approach to these things.
1. PBS == Public Broadcasting System, i.e. publicly funded television, in the U.S. That's been taking on more and more commercial tinges, in return for corporate sponsorships, as the public money has fallen short.
Rather, of people promoting [product] without having real knowledge of it, including appropriate application and dosage.
This would be more in the vein of traditional Chinese medicine. Only, "intuitively", without the normal training and basis in extensive empirical observation condensed into an effective curriculum, apprenticeship, or similar proven method of conveyance.
Does that mean that you could get the same effect from consuming MSG?
Interesting. I've tried L-glutamine, also several times at common dosages, and it makes me feel strange, like calm on the one hand, while edgy on the other hand. It's difficult to explain, but my voice felt calmer and my ears felt more anxious. I first thought the product I bought was contaminated, so I tried two more brands, with the same effect.
One thing is for sure: L-glutamine has much more effect on me than L-theanine (which basically does nothing).
15 - 30 minutes into one starter dose, and I felt terribly worse.
No professional explanation. It was only years later, when I ran across reporting about serotonin poisoning, that I had a possible explanation. The symptoms certainly fit.
A friend has used Zoloft for years, to what she feels is positive effect. And in many ways, we are fairly similar -- certainly, our psychological profiles align substantially.
Nonetheless, what works for her, does not for me at all.
I've experienced it once, after a particularly incompetent new pain management doctor made me try a cocktail of anti-depressants for pain relief. (their reasoning being that "it's all in your head"). I felt utterly awful, pulse racing, severe anxiety and horrible mixing of panic and terror.
It's imperative that people on multiple medications take Serotonin Syndrome very, very seriously. I'm very sorry you experienced it, I wouldn't wish it upon anyone.
(The pain management doctor was fired a couple of months later by the university hospital. Complaints from patients, nurses, pharmacists and insurers had been mounting.)
I'd say 10-20% of the time that I take it, I am unable to fall asleep and don't become tired. The longer I stay away, I feel incredibly restless and twitchy to the point of actual anger. I'll lie awake in bed until 5 or 6 AM (after taking melatonin at 11pm or midnight). It gets to the point where I feel like I need to do some kind of physical activity in order to relax. My eyes and chest often feel heavy but my legs are tense, restless and twitch.
Sure seems like Restless Leg Syndrome just from proof reading this. Based on my first look into RLS just now, there could be a link to low Vitamin B, which could be triggered from a Saturday of drinking and then expecting melatonin on Sunday to set me up for a productive Monday.
But with tea, I just get nervous and irritable. Maybe weaker tea would be better. Or green tea, rather than fermented. Yes?
For what it's worth, I've been diagnosed bipolar, and take modafinil. So perhaps I respond atypically to caffeine vs L-theanine.
I wouldn't worry about it unless you're taking tons of supplements every day by the handful or if you're a heavy drinker. However, do get physicals at least once a year with a liver panel that can track if your liver starts to degrade. Liver disease is generally a slowly developing chronic condition tied to lifestyle so you can usually right the ship if you're mindful of the risks.
Take it with a cup of coffee and the caffeine boost lasts longer and is much smoother.
Is this... Safe? I mean, if I told me dentist this she would slap me, let alone my cardiologist.
Maybe it's border line if you already have arrhythmia, but recent studies seems to show positive effects up to that limit, and it doesn't seem to cause arrhythmia.
Might upset your stomach though, but I'm pretty sure your dentist will be happy to polish your teeth for a modest price...
There seems to be several positive effects on breast cancer , diabetes, Parkinsons, ms, and stroke.
One of them: https://academic.oup.com/aje/article/180/8/763/2739131
I'm past the "beneficial" range of caffeine consumption, though.
If taken alone, it's also pretty good at providing a general reduction in anxiety. I was travelling internationally one time with a co-worker who had a very low grade anxiety attack. Due to the circumstances our options for getting him medication or seeing an actual doctor were limited. I offered him some L-Theanine and he LOVED it, he said it calmed him down just enough the rest of the trip that he wasn't concerned with having another attack. Obviously, this isn't medical advice and ideally he would have seen an actual doctor, but in this case it was really effective. I will say that taking it without caffeine comes with a bit of sleepyness. Definitely a potent combo when taken with Melatonin and a lot of OTC sleep aids will combine the two.
I wonder, though, what long-term side effects L-theanine supplement might cause. I searched several times but most information on long-term consumption is anecdotal.
The best site on the Web for summaries of studies on supplement efficacy appears to be:
Why wouldn't the L-theanine solution be L-theanine in water? Including tea would introduce other chemicals, including caffeine, no?
Gail Owen is an employee of Unilever, which markets food
products some of which contain L-theanine and caffeine."
My fancy loose leaf tea habit is about $6 a week, or about one latte with tax and tip. It's cheaper, fewer calories, and I don't get agitated like I occasionally do with coffee on an empty stomach. You still get away from your desk (which I think is half the point of going for a coffee anyway), but not for as long.
My dealer knows that some teas will keep you awake and some that won't. Some will have that info but maybe not know the connection with l-theanine.
Outlined in this paper "Risk Assessment of Fluoride Intake from Tea in the Republic of Ireland and its Implications for Public Health and Water Fluoridation"
Edit: spelling and comprehension corrected; pre-tea morning fog.
So, only a problem in countries that do fluoridation. (I didn't know that that was the case in Ireland. This definitely reduces the chance of me ever moving there.)
If I have to very charitable, it probably reduces jitters that I otherwise get from coffee-only. But I'm not sure if it's a real effect or a placebo.
Science has proven this can have an affect. But even the study doesn't conclude this is 100% for everyone.
It's interesting how many brands Unilever owns:
Unilever's tea beverage market share worldwide is estimated to be 11.1 percent in 2016. Source:Statistica
Unsure if you are a part of the viral campaign yourself or if it was just a subtle joke...
Also, wow I am surprised at how much of the Ice Cream industry they own.
Is having a 0.3mV2 difference in alpha waves significant?
Ive tried taking lTheanine and it doesnt seem to do much, even if I take many pills.
wonder if there's a way to package l-theanine and caffeine together into one supplement. maybe that's what those gas station "super focus!!1" pills use? i might give it a try this upcoming semester, i generally don't mind being a supplements guinea pig.
It's called "tea".
Stuff which modifies them greatly as this study seems to show probably has some sort of side effects.
Otherwise nature would have boosted them already.
A few thousand years is not a long time in evolutionary terms.
Like ... food? This is an amino acid, the building block of protein. Many amino acids have pronounced effect in the body or when lacking.
Our bodies are fine-tuned to be somewhat fault-tolerant, but evolution is extraordinarily slow. If our diets diverge over a few hundred years, there haven't been nearly enough evolutionary cycles to compensate for whatever effect that has; particularly if it's minor annoyances like getting jittery with coffee, which was consumed far less as far back as a few hundred years ago.
Wouldn't this entirely depend on selection pressure, rate of mutation, and turnover of, er, subjects? Certainly bacteria can evolve extremely rapidly and it's been noted in animals too, cf http://discovermagazine.com/2015/march/19-life-in-the-fast-l...
Certainly for the average office drone today, spear chucking muscles are atrophied, yet the thrill mood of hunting down and eliminating software bugs remains, pattern matching previous hunts, soaking in the environment, looking for signs, tracking, going in for the kill, the happy drudgery of dragging the kill back to the tribe or the paperwork of closing the bug out in the tribe's bug tracker and doing some git merges. Or tapping out calm tranquilized grind of endless lines of boilerplate java code feels like harvesting endless rows of cultivated berries. I wouldn't say the mood of labor has changed very much in some millennia, although the exact ratios of who's permitted the thrill of the hunt has varied over economic eras.