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> However, combinations where the ring finger is up while its neighbors are down is physiologically problematic.

Really? Why?

Because the middle, ring, and pinky all share the same muscle group.

Try this: hold your hand out in a fist and extend your middle, ring, and pinky straight out. Now try to flex each of the three extended fingers individually without moving the other two.

Now try the inverse: make a fist and try raising each finger individually without moving the other two. It's physiologically impossible because the muscle used for extension is shared between those fingers.

(Edit: extension is impossible, not contraction)

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