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I work remotely so the only person in my home office is my wife who also has a remote job. I use headphones and we have a general understanding that during work hours we limit idle chit chat and if headphones are on, shoot each other a text.

For co-workers, they are also remote so we schedule meetings and chats. If something comes up we ask when we could interrupt via chat and the person responds when they can.

If the end of the day comes and a person hasn't responded we shoot an e-mail to get on the radar for the next day with the understanding that it should be handled asap the next day before entering a heads-down mode.

If extremely urgent then we pick up the phone.

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