Spent good amount of time on reading about it, some books I read:
* 10% Human: How Your Body’s Microbes Hold the Key to Health and Happiness (https://www.amazon.in/10-Human-Microbes-Health-Happiness/dp/...)
* Gut: The Inside Story of Our Body's Most Under-Rated Organ (https://www.amazon.in/gp/product/938528861X)
* Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brainfor Life (https://www.amazon.in/dp/0316380105)
also watched the course on Coursera about Microbiome (https://www.coursera.org/learn/microbiome), it was an eye opener.
* Less refined/junk food
* Limited use of antibiotics
* More greens
* Add curd/yogurt (in not allergic in your diet)
* More dry fruits, nuts
I've met a a number of people that think this way. As if the whole of the body's digestive and immune system serves no purpose simply because it's complex and we don't understand it well enough.
I am very happy to have gotten the opportunity to work there, and sometimes I wish I hadn't left. My non-compete is finally up at least!
The amazing thing is this diet (The Specific Carbohydrate Diet) has been successfully used by people for several decades. Unfortunately, despite recent progress in terms of scientific studies validating its effectiveness, many gastroenterologists still say that diet has little to no effect on Crohn's disease.
Fortunately, not everyone is in denial, and it is finally starting to gain acceptance in the medical and the research community.
So, what to do? I remembered reading some research which connected the cases of low antibiotic efficiency with bacteria organization into biofilms. Given that both - Xifaxan, which acts mainly in the internal space of the intestine, and the amoxicillin, which acts from the blood, ie. from the inside of intestinal wall, didn't work well, it suggested to me that the bacteria is probably biofilmed upon and inside the mucous layer. So basically i needed to scrub clean the surface of my intestines. High skilled yoga practitioners do self-cleaning by chewing on a length of cloth and passing it that way through the body - well, now i understood why they would do it :) Not having yoga skills and thinking engineering way - i needed something like a laxative which would be sucking the water through and off the intestinal walls (i.e. washing the biofilms/colonies off the walls and down) and would start doing it right in the upper small intestine (the breath test shown that i had the bacterial overgrowth starting in the upper small intestine). The first Google search brought it right away - salt water flush. Once i saw it, i didn't even have the patience to go to store for the recommended pink Himalayan salt as it was pretty obvious that salt(ie. NaCl) itself is the key here as the salt acts exactly the way i needed. I just rushed to the kitchen (i got so tired of SIBO for all those years) and used the regular one. 3 hours later the effect on the SIBO was stronger than that from a round of antibiotic. That week i repeated it 4 more times (with the recommended pink Hymalayan salt as actually it tastes better :). For several weeks after - 1-2 times/week. Last week didn't have to do it at all. SIBO is known to have high return rate, and i'm absolutely not bothered by it as the procedure can easily be repeated if/when it becomes needed and not that bacteria can develop resistance to it.
I've found it to be pretty interesting and accessible if the subject interests you.
i can see 1) being true. 2) potentially is true, though i don't have the expertise to evaluate this. however, some companeis are genetically engineering microbes to increase effectiveness, which would add to the time requried to "optimize" the microbe. for 3), ive heard differing opinions. "the tox is in the dose", so even if ppl have ingested a microbe without harm, if you increase the amount of microbe who knows what will happen.
nonetheless, their approach is interesting. the idea is that circulating immune cells (dendritic cells and macrophages) "sample" the gut microbiome by sticking tendrils through the intestinal wall. they collect antigens from the gut and then migrate to regional lymph nodes (basins with a bunch of immune cells) and interact with t cells and other immune cells, changing how they function. they have a platform where they screen a bunch of different microbe strains in culture with dendritic cells (and maybe other cells) and then measure what cytokines and other chemicals the dendritic cells secrete / express. they select microbes that have the ideal "immunophenotype" to use as therapies. they then validate these in animal models of disease, and have some really impressive preliminary results (summary of data in the IPO prospectus)
of course, as the article states, the big question is whether this will work in people. there's conflicting evidence as to what particular strain is most implicated in a particular cancer. and we also don't really know if just hitting one strain is enough to do anything. part of what makes evelo interesting is that they think theyve found a specific immunological mechanism for their microbes role in disease, which makes it easier to measure whether its working in early studies (ie you can measure circulating cytokine and immune cell populations as a proxy for whether the cancer is getting better). however, theres no way to know without doing the human studies. this phenomenon applies to all types of drugs however, and is the reason why drug r&d is so expensive: you never know if something works until you test in humans, and thats really expensive