> She sniffed six sweaty tees from people diagnosed with Parkinson’s, and six from healthy controls. Milne correctly identified which six had Parkinson’s, but she also tagged one of the control subjects as having the disease.
> Despite that error, Barran was intrigued—all the more so eight months later, when the same supposedly healthy control subject Milne had identified was diagnosed with Parkinson’s.
> "Our previous work in a mouse model found that malaria infection altered the odors of infected mice in ways that made them more attractive to mosquitoes, particularly at a stage of infection where the transmissible stage of the parasite was present at high levels[...]"
In turn, this reminds me of a spate of articles that hit ~2y ago on T. Gondii, which appears to alter the scent of host cats' urine to make it more appealing to prey animals: https://en.wikipedia.org/wiki/Toxoplasma_gondii
Malaria has this smell. I can't describe it, I can only say that it's not unpleasant, but anyone who's tended to someone with the disease knows what I mean. The sweat, the breath, even the room the person lay in, it just has this smell.
Curious for two reasons: the top-level comment here on some people being able to diagnose Parkinson's by smell, and my own experience being exposed to people experiencing malaria (albeit in a non-clinical setting with _plenty_ of other overwhelming smells) and not registering a common olfactory experience.
So, if you want to replicate smell, are you talking about replicating the particular suite of chemosensors all humans have in common? Some particular human? All animals? Or, are you not so much talking about odor (the thing that anythinghas evolved to detect) as chemical volatiles generally?
Even then, we need to manufacture something much like chemosensors to detect any particular chemical volatile—we have to be explicit about what we’re looking for, and won’t see anything we don’t know to look for. (You can use a mass spectrometer, but you’re not getting molecules from that, just atomic isotopes; and you’re not getting just volatiles, but the whole fluid containing the volatiles.)
I guess, depending on context, you can answer these question like for the other senses. E.g. humans cannot hear above a certain frequency, where some animals can. Some humans have reduced ability to see "green" (the most common form of colorblindness), etc. That doesn't mean we can't measure or reproduce audio and video in a meaningful way, of course.
I know you're being obtuse, but based on what's in this article you really don't have a way to find malaria if all you're getting is a general malodor.