As with so many things, any defects must be measured from a wider scope within which comparisons can be made. Corrections can also be incredibly difficult or just costly, if a positive direction can even be identified.
This is possible, but I've found many/most adults are observant enough to comprehend their incompatibility with local culture. However, a smaller percentage of them attempt to do anything about it (e.g. too apathetic, depression, etc.).
>By definition (and I share the original post's issues above), a subject in this state is already far enough out of calibration that they cannot self-diagnose issues, let alone work towards correcting them.
I disagree. I would split these people into two groups: Those who have self awareness and those who do not. And then, those in the self awareness group would be split between those who are ready to attempt change, and those who are not. This is harsh, and I hope I'm wrong: I think the non-self-aware are incapable of being helped or changing. I think that's the group you are referring to.
[Note: this assumes we are talking about the subject of the OP/article. More so than less psychologically healthy lonely adults]