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1) There are a lot of studies showing an increased risk of various conditions, e.g. heart problems for babies conceived with ICSI.

2) It stands to reason that while some infertility is caused by issues that having nothing to do with the genetics of the sperm or egg (e.g. vitamin E deficiency), other cases may be caused by genetic conditions that have coevolved to cause fertility issues to prevent them from being passed along.

3) You'd have to completely rule out the possibility of sexual selection at the gamete level, even though this idea has been gaining traction in the last few years.




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