The biggest difference is not squatting to use the toilet. Until modern toilets, humans squat without sitting to poop. More sitting = less squatting, which leads to not squatting to pick up things since our muscles are underdeveloped.
I believe it's part of the reason my upper leg muscles have remained strong even when work has put a halt on exercise for longer periods of time.
I would be open about this if asked but never bring it up unsolicited in conversation as in the past I have found it regarded as outright bizarre.