I'm still using Adobe Fireworks CS5 (released in 2010).
I use it every day, but I can’t imagine paying monthly for it. It might sound silly for the SaaS folks, but I grew up buying desktop software, and it feels insane to pay for it as a subscription.
(Incidentally, I also use Transmit FTP, Screenflow, and Deckset almost daily as well. They're not SaaS. I happily pay for new version upgrades if I feel I need the new improvements).
* famiROM & yychr for NES homebrew development
* QBasic on Windows 95 for a pet project
* Using Illustrator and InDesign CS2 for my book design hobby
* ReplicatorG for 3d printing as MakerBot's new software is incredibly finicky on my Windows 7 laptop for some reason
* Google Sketchup because it's the only CAD program I know how to use well (thanks middle school 'tech' class!)