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Not sure if it counts, but High Performance Python[0] starts you out from the bottom explaining the hardware and how it has to process your code, and they go from there. It's a really good read, was recommended by a coworker and I haven't had issues reading through it so far. Also you might learn things to consider when writing or refactoring Python code that affect performance (I always suggest never to "solve" a performance issue that isn't there yet but to instead write something that works first, then try to optimize the code once it works).

http://shop.oreilly.com/product/0636920028963.do




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