It very much is a mind-body thing because ultimately the brain gets signals from the body and it is the mind that determines if those signals are pain or just noise.
I think also situations of social inequality are feeding the opioid crisis. Black people in America were early adopters of trends such as the breakdown of the family and believing that "there ain't no making it" and now we are seeing that rural whites are experiencing these.
A problem they have been trying to solve for 100+ years. This is a solution they have worked very hard on. The fact that it is also a very profitable tool for social control is a bonus.
Increasing housing supply in silicon valley and subsidizing moving are the cure
I understand that is a positive so long as it is good, as a change of lifestyle seems to help kick some addiction - but there needs to be something to ensure they don't wind up in the same place in a new city.
I read a bit about this when I first heard about it approximately a year ago, and as far as I can tell, there's no clean solution. There are essentially two main components of the opioid crisis:
1. Overprescription of opioid CPDs (controlled prescription drugs).
2. An influx of heroin provided by the cartels over the southern border.
In order to make headway in this issue, both of these sources need to be addressed ASAP. I know that for some people weaker painkillers do very little for them (vicodin does very little for me), but excesses in peoples prescriptions (getting 30+ when they need <10) and increasing prescription rates over the last two decades are huge contributors to the current crisis. And, despite the fact that border security has recently been taken up as a mantra for arbitrary bigotry, it might be necessary to qualm this crisis. I hate to say it, but if the wall could help, then building it might not be such a bad thing.
Some important points:
1. Opiate and benzodiazepine CPDs cause more deaths than heroin and cocaine combined, and have since 2002 (25,760 deaths in 2014).
2. The population of abusers of heroin is approximately one tenth of the population of abusers of CPDs. However, the number of deaths due to heroin is approximately half of those due to CPDs.
3. From 2002-2011 the number of CPD abusers initiating heroin use was 3.6% of the total number of CPD abusers 2002-2011, but was 79% of new heroin abusers because the size difference between the CPD/heroin abuser populations.
4. In 2013, the CPD abuser population was estimated to be 15x the heroin abuser population. In 2013, it was estimated to be 10x.
5. In 2013, 78% of heroin admissions had been in treatment once before and 27% had been in treatment five or more times before - in other words, the relapse rate is extremely high.
6. Comparison between opioid medication prescription rate  and deaths due to heroin OD per 100000 [1, pg. 55].
For anyone who isn't alarmed by the opioid crises, here's a statistic on deaths in the USA due to heroin overdose by year (which the CDC estimates is undercounted by as much as 30%!):
2015: 12989 
And don't forget the 250% jump from 2013-14 in Fentanyl-related deaths !