Your response is useful. Thanks.
I don't want this to be out of context. Here exactly my original comment:
I assumed in his context he means you are a biological entity but there is not correlation with the abstract entity (the mind). Because of that you can state your personal interests are not linked with your DNA in any way. But this has been probed to be false. Scientist have observed a high correlation between the testosterone and the social skills and interests. As the testosterone that is generated based on our DNA you can link you abstract entity with your physical entity. So scientist can predict how social are you going to be or whether you will be more interested in dolls or mechanical objects before you have even be born.
This is the biological factor, and then you have the cultural factor, the one you call "the ought to be". So genetically you have a predisposition to be one way, but this can be shaped by the environment, not only because you can reason about your behavior and change it but because the environment also modifies the DNA and so the levels of testosterone (and more things). How much can you shape the biological predisposition is a good question to answer. For example: I could say that being gay or straight is a biological factor but I doubt any environment factor can change that, maybe you will fake it for the shake of the social acceptance but not changing it.
EDIT: I forgot to say that the testosterone has an influence in the plasticity of the brain.