No, they're merkled, so it doesn't.
> I suppose block size increases the network latency for advertising solved blocks... but going from 100k to 250k every 10 minutes does not strike me as being particularly problematic.
Doesn't matter how often it is, I find a block, I mine the child immediately. You have to wait until you've received and validated the block. It's all about latency.
> Also, I'm trying to verify your claim and I can't see any evidence of it. It appears that different clients were using different block sizes for a long time. The maximum block size on the BTC network has been over 250K since 2013, according to . Also take a look of this graph of orphaned blocks 
Yep, this is now ancient history. Mean blocksizes tend to mask what's really happening, but I recall the orphaning problem and ghash.io spike personally.
And blockchain.info's orphan block measurements are completely unreliable :(
More background: https://rusty.ozlabs.org/?p=535 (my blog)