MIT grad, data scientist here. Again, if you are not a top data scientist, it will work fine for you. I routinely get offered $300K/year as a recent PhD grad in the Bay area. I would not get anywhere near proportional compensation in Atlanta or even Seattle.
I'm not going to pretend this is scientific in any way, but using online COL calculators (http://money.cnn.com/calculator/pf/cost-of-living/index.html), $300k in San Francisco is supposedly (taken with many grains of salt) equivalent to $172k in Atlanta, which you could surely land?
For most Americans that's pretty close to being correct - the average savings rate is around 6%. (https://www.fool.com/investing/2016/10/03/heres-the-average-...)
This would be quite difficult for someone on an average salary with kids, or sometime who works in an industry where keeping up appearances is important.
Vacation costs, Amazon splurges, etc, don't change between Akron and SF.