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For anyone interested -- this model is called Wake therapy.

https://en.m.wikipedia.org/wiki/Wake_therapy

https://www.scientificamerican.com/article/fighting-depressi...

> In the new study, published online January 15 in the journal Translational Psychiatry, the scientists investigated whether this process is responsible for the antidepressant effects of sleep deprivation. Mice with depressivelike symptoms were administered three doses of a compound that triggers adenosine receptors, thus mimicking sleep deprivation. Although the mice continued to sleep normally, after 12 hours they showed a rapid improvement in mood and behavior, which lasted for 48 hours.

> The results confirm that the adenosine buildup is responsible for the antidepressant effects of a lack of sleep. This finding points to a promising target for new drug development because it suggests that mimicking sleep deprivation chemically may offer the antidepressant benefits without the unwanted side effects of actually skipping sleep. Such an intervention could offer immediate relief from depression, in stark contrast with traditional antidepressants, which take six to eight weeks to kick in.

Curious if it'll be mimicked somehow in the form of drugs in the future.




This is reassuring. I've done this a lot over the years, and found I enjoy life a lot more when I do this intermittently.


Interesting, as Modafinil has (one of many) mechanisms of action of reuptaking intracellular adenosine; and is also a mild anti-depressant


Although I've noticed that the come down for me feels like the comedown off some anti-anxiety medicines or amphetamines. It certainly works as a mild anti-depressant while the drug is working.


This is interesting, but isn't it a purely acute effect?

Like, you stop feeling better around the time you stop feeling dazed and exhausted. I can see the urge to get it into drug form, it's impressively powerful, but it looks like the mechanism of action and the mechanism of the side effects are both adenosine.


It would be handy in pill form, because keeping my eyes open for that long was quite tedious.


Anecdotally, I've done exactly this using amphetamine, 1,3-DMBA and modafinil. The former mainly because I couldn't sleep (due to taking it for recreational reasons) and just decided keep going until the next night (not taking any more, of course!) to not screw up my sleeping pattern too badly. It definitely does have some interesting effects mentally, though using stimulants to induce it has its downsides due to screwing with chemicals and complex biological systems!


And taking the kind of pill that keeps you awake is probably counterproductive :)




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