I was speaking of norm for the body, not norm of what most people do. In any case, my point was "restriction" isn't a restriction if you're over-consuming to begin with. It's a language/communication issue. Telling people to reduce (when they think they're normal") is, imho, the wrong message. We've normalized obesity by, to some extent, allowing people to believe obesity is perfectly normal.
As for sedentary lifestyle and obesity...those are symptoms. What happens in the body is, often, inflammation. Inflammation in turn gets manifested as various diseases. Obesity is not what kills you per se. But it does trigger various things (often rooted in inflammation) that will.
Regardless, in the context of the original article, I was simply taking a stand at why CR increases lifespan.
I hear ya. We're on the same page, mostly. I just wanted to clarify my particular thoughts.
Almost no one actually thinks obesity is normal. a very small set of people argue it's healthy, but that is a tiny minority.
As for "norm", caloric restriction is not about being normal weight. Caloric restriction is about cutting calories significantly below the level needed to maintain a normal weight. I don't see any way to argue that this is "normal".
> As for sedentary lifestyle and obesity...those are symptoms. What happens in the body is, often, inflammation. Inflammation in turn gets manifested as various diseases. Obesity is not what kills you per se. But it does trigger various things (often rooted in inflammation) that will.
All indications are that sedentary lifestyle is a root cause, not a symptom. Obesity is perhaps a symptom, but sedentary lifestyle is a step before that.
I don't believe there's actually any evidence for the claim that inflammation is the root issue for most disease. I get the distinct impression that this is a pseudoscience claim made by people who are selling quick fixes (as opposed to the diet and exercise people already know they need). "Inflammation" is almost a magical claim. It sounds scientific but there doesn't generally seem to be any actual science behind claims of inflammation causing arbitrary health issues.
I don't believe there's actually any evidence for the
claim that inflammation is the root issue for most disease
Inflammation forms the basis of many physiological and
pathological processes. Much is known about how
inflammation is initiated, develops and resolves over the
short term. But less is known about the causes and
consequences of chronic inflammation, which underlies many
human diseases. Recent studies have extended our
understanding of chronic inflammation and the cross-talk
that occurs between inflammatory responses and other
physiological and pathological
Perhaps. But do you have a better term for "completely fucking over your normal body processes"?
I was using inflammation as a generic term for "disrupting the baseline." Sorry. You're correct. I'll try to be more particular next time.
You've lumped literally all illnesses together (anything that disrupts the baseline) and referred to them as "inflammation". This is exactly what I'm criticizing. Inflammation in this context is a meaningless term used to give an appearance of medicine to pseudoscience.
There is growing evidence that it is in the chain of causality for lots of diseases where it has previously not been thought of, and that lots of inflammatory conditions seem to be linked manifestations of common systemic causes rather than localised inflammation with unrelated causes.
This does get overplayed sometimes into “everything starts with inflammation”.
Jokes aside, I see it differently. Much.
First, look around. Obesity is normalized. Those less so, look around and think "I'm okay...Look at that guy/gal..." We (speaking for the USA) got here because humans do what they do. In this case, they define norm by what they see.
I'm not concerned about those who argue it's healty. My concern is those who do not. Think of the current politics and healthcare. NO ONE brings up the fact that if we prevented what we could prevent, there'd be money for real illness.
As it is, we have fat people eating donuts, drinking milk by the gallon, and complaining about their premiums. That would be funny, if it wasn't so absurd.