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There is a limit to the flexibility of the brain. In a compensated brain, it is very likely that an injury that would normally not have any effect on function would have devastating consequences.

To answer your question, I'd imagine that it likely depends on the timescale. People with TIAs have decrease in function that lasts minutes to hours, and on return of proper bloodflow, might take days to fully recover. You might see this as people who completely lose speech during the TIA, and then have word hunting for several days.

A brain that adapted to gradually diminished function, say as a result of microvascular changes, over the course of months to years would likely experience the same debilitation if there was a sudden permanent change.




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