I don't this is true across the board, but the challenge is finding a "job" that you love and are excited to tackle every day. This will differ for most people, but the closer you can get to doing something that you would voluntarily want to do even if you weren't being paid for it the better mental space you will be in.
Personally, I'm still searching for that magic job but through trial-and-error I'm getting pretty good at identifying what I don't want to do.
Knowing what you DON'T want to do is sometimes more important and useful than knowing what you DO want to do!
This is great and very important, but it doesn't prevent burnout necessarily. I have a job and career that I really enjoy and consider to be very meaningful (aging research), but I have been severely burned out several times.
In some perverse ways, having a "meaningful" job can increase stress and propensity to burnout exactly because you know it's important. I imagine this is why doctors and lawyers have a lot of burnout, stress, and substance abuse problems. OTOH, you don't really hear about corporate accountants getting burned out.
My personal theory of burnout is that it happens when you start to feel you are on a treadmill -- running hard to achieve an important goal, but getting nowhere. Then the stress and burnout symptoms increasingly make this a self-fulfilling prophecy and feedback loop.