Great context for the article is a book I'm currently reading: Small Giants. Its about companies that could be large choose to stay small and intimate.
I'm not really a fan of the build a company that needs investment in large quantities to grow and eventually be sold. I'd much rather build something that is useful, makes good money, and lets me work with a great+small team. I'm currently fighting this battle with Cloudomatic. I don't really want to build a large vc backed business, but it looks like we have to in order to really achieve our long term goals.