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If you want performance don't use Python.

I hope the downvotes are not due to people thinking you can actually write high performance applications in Python.

Sadly true. Python is great for scripting, but "high performance Python" is frequently a challenge better suited to other tools.

"High performance Python" is usually done by "offloading literally everything to native extensions" :D

Until JIT authors start taking advantage of the frame execution API that was added in 3.6.

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