For those unfamiliar, a healthy brain has what is called neurovascular coupling where the amount of blood flow into local clusters of neurons (order of millimeters) is adjusted based on demand (order of seconds). Simple optimization strategy. With MRI T2* imaging we are able to measure blood flow because the ratio of oxy-/deoxy-hemoglobin subtly alters the magnetic field. So if you take a picture of the brain every 2 seconds you get "blood flow" and if the average signal in 2 areas have a similar shape, we say they are "functionally connected." Just good to keep in mind because it's an area of research particularly prone to misunderstanding.
not so hard to understand:
The "functional" is because these analysis were usually applied to a specific task condition, thus function specific.
"similar shape" or "connectivity" is operationalized by correlation, though there are many other ways.
That being said, I highly recommend it, but to be used with caution.
By the way, if you take this drug, you will notice your urine will smell differently (different chemical composition). That (logically) means that your body either retains something it should have gotten rid of or the opposite, meaning your are changing the chemical composition of your body. Science has no idea how this drug actually works (we only know that there is some kind of effect) and has no idea what its long-term effects are.
A change in the chemical composition of urine strongly suggests a change in the body, but doesn't "logically" prove it. In the simplest case you could imagine consuming some kind of dye which is simply excreted and not metabolized, which could change the appearance of your urine, kind of like in
(where the urine change itself mainly reflects what the body did not absorb).
Another possibility is that the body breaks down the drug and excretes all of the reaction products. In principle, that could occur without consuming any other substance, just by applying energy to cause a reaction to occur, or by providing a catalyst.
Also, some chemical changes in the body are beneficial (though the typical random change is most likely not).
By threshold dose I mean take no more than is needed to get an effect. I experimented a bit and found 50-100mg of modafinil (1/4 to 1/2 pill) to be effective and have never taken 200mg.
Escalation on tolerance is the exact opposite of what you want. On the first hint of tolerance, stop. Again think about the control system at work. Your body is trying to maintain homeostasis, which is usually a very good thing.
It doesn't give the "alertness or kick" of coffee but it gets you in this mood of "do things".
I am a bit worried about the side effects so I haven't ever taken more than thrice a week. Unlike many others who report I don't any changes in mood. Its easy to stretch your days after so you got to be careful not to over burn yourself for the day.
Also I get a really good night sleep after a day of 'killing it' - which may just because of feeling good as a result of getting things done.
This sounds ideal. Like pretty much anything, I can testify that in my experience you can develop tolerance and it loses its effectiveness (at least for cognition) when taken daily.
How much of that is placebo? i.e. "You're doing things because you know you're taking something that helps you do things?" Productivity comparisons with a placebo haven't been conducted yet, but I'll bet it will be rather underwhelming as a motivational agent. Especially when you compare it to other stimulants like Coffee, it will sound even less miraculous.
The silver bullet of psychopharmacological brain-enhancement hasn't been found yet. That's the holy grail.
You know how you get "tired", and want to take a break? Still happens.
You know how you get "sleepy" and can't keep your eyes open? That's completely gone. It's a very strange feeling.
How have managed to avoid tolerance ?
I've avoided tolerance by not continuously taking it - if I'm no longer noticing the effects as much, I come off for a while until I really need it again. That seems to have stopped me from building up a lasting tolerance.
And another quick question what is ur schedule? What time do you take it?
I take it whenever I feel like I need a boost of concentration, it usually lasts about 6-8 hours so the latest I'll take it is 6pm if I want to sleep that night.
Also, placebos have side effects.
Not saying it doesn't have effects for some people but it's probably mainly placebo.
Here's a quick primer (with 73 citations): https://examine.com/supplements/modafinil/
("Mental noise" is one of the symptoms of ADHD too.)
But caffeine makes it hard to sleep and the adrenaline rush isn't so good for you.
My advice to people is to quit one at a time. Take a few days (or even a week) to taper each one down to 0 separately.
Surgery is intense and also costs 100k (it is out of network for every major PPO insurance). The most likely to be successful procedure entails painfully breaking your jaw and moving it forward with metal plates. The recovery is brutal and requires a month long Soylent diet. Other procedures involve iteratively carving out more and more soft tissue in your tonsils until there is no more obstruction.
Sleep apnea treatment is still a pretty unsolved problem in medicine. Only half of patients end up complying with wearing the very uncomfortable CPAP breathing mask for more than four hours a night, most can't even tolerate it at all.
Also there is a dental appliance that pushes the lower jaw forward to open the airways. Look into that. If your insurance doesnt cover it you can buy an off-label "anti-snore" boil-and-bite device that does the same thing.
No. I weigh 150 lbs (6 feet tall), same since high school.
> Do you eat a simple diet that takes account of possible allergies?
No allergies, and I'm doing better now with diet.
> Do you get a lot of exercise?
I run 2-3 days a week (2-3 miles per run). Used to be a state competitor in high school for distance running.
> Do you work at a desk job in a hunched position that has curved your spine and pushed vertebrae into your throat?
Absolutely. I sit at my desk 10+ hours a day, and my posture definitely could be a hell of a lot better.
Remember, obstructive sleep apnea is caused by a physical _obstruction_. You need to either address the obstruction by splinting it open using pressurized air (CPAP) or by physically making more room via surgical techniques.
Ingesting herbs doesn't address anything in terms of there being an obstruction, so it doesn't treat sleep apnea.
EDIT: Why am I getting downvoted? I am suffering from a debilitating medical disorder, and people are suggesting I need to drink snake oil or accept the flying spaghetti monster in order to heal myself. Of course, I am going to get a little upset. Please try to understand my perspective.
Like most technologists who frequent this site, I'm all for following the scientific method and gathering data through repeatable experiments that test hypotheses, and I'm against petty tradition ("we've always done it this way" is a very counterproductive/backwards way of thinking that also precludes progress -- as an entrepreneurial community, we tend to think differently and to challenge established beliefs here on HN).
I'd be very interested in reading them.
Nevertheless, I will still provide you with some samples of evidence (these are high level summaries but actual studies are linked within:
I just don't see how any of these can _possibly_ resolve _obstructive_ sleep apnea. For example, if you have a large tongue and it collapses in your sleep, I don't see how you can solve that by meditating. That's physically impossible.
It's very easy to see whether something has any sort of effect on your apnea; you sleep every night, and the difference is readily noticeable.
So the point is to perhaps be a bit more open minded and look into someone's suggestion rather than writing them off with a snide comment. There may or may not be something more to what they are saying, but you will never know if you think you somehow have the upper hand on truth over everyone else that ever existed.
Do you have the same experience each time?
I'd be interested in an slow release format since the drug can be bought over the counter where I live.
Though it's not even in the same ballpark as amphetamine. I fly back to the States just to re-up my Vyvanse prescription.
I couldn't even feel the Modafinil on day 3 without taking 5x the dose. That's a bit silly.
Instant release amphetamine ends up being more like a party drug for the same reason, though less extreme.
Compare that to a slow release amphetamine (prodrug) like Vyvanse where most people can hit a 2+ week cycle of constant use, or an indefinite cycle by only dosing a fraction of the week.
There are some days I wouldn't even know whether it was working until I looked back at my productivity in hindsight.
When things like this get talked about outside of their focus spheres, that's when things start getting shut down because the agencies are publicly pressured to do something.
A lot of research went into this to emulate tech knowledge enough to make it convincing.
It was worth it though and obviously is just about to pay off as they arrest some 20 people for ordering 50 Modafinil tablets and give them 2 months probation and a $500 fine (or whatever the penalty is).
We all know it had to be done however because Modafinil is in the news near daily with the wrecked communities and terrible life destroying addiction leading to violent crime.
Very smart and tricky on their part.
Very low RoI. Agent should be fired.
"Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil, resulting in very similar pharmacological effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream."
You should monitor your kidney enzymes if using it long-term; I've never had any issues.
Plenty of places selling it for $20/30 300mg caps via Google Shopping search.
I don't think there are (m)any cases of people being busted for importing/simple possession, but if you were to get arrested for something else and had it on you, I wouldn't be surprised if you get additional charges.
Point being, this isn't a legal supplement you're ordering through the US Postal Service.
- Shipments are occasionally seized by customs, so don't put all your eggs in one basket. Just a risk that's part of the game. Never happened to me though.
- Credit card theft happens, even with legit vendors... based on what I've read, sometimes (often?) it happens in the maze of overseas banks, credit card processors, etc. So general consensus seems to be that buying with bitcoin is best. While a crooked vendor could rip you off just as easily over bitcoin, anecdotally the success rate seems higher with bitcoin. Often you get a discount as well for using bitcoin!
I live in India so Moda is also incredibly cheap for me - about $0.15 per tablet. Plus, it's available without a prescription.
Do you guys honestly feel that you're not smart or concentrated enough? Or are you just trying to improve these traits to the max and beyond because they're considered to be virtious in the culture around you?
> If you have “an Everest of work”, the solution is to get less work, not to take drugs. Be the person you are.
Did anyone doubt this at the start of the study? I bet Tylenol modulates cortico-cerebellar connectivity. Pretty weak conclusion. I hate to be so critical, but I'm not sure what is added. Drawing real-world implications is likely impossible, which admittedly may not have been the authors' goal.
Getting work done while feeling ill is more, not less difficult!
Study participants received a single-dose of modafinil or a placebo pill.
All subjects then underwent two fMRI scans, performed before and 3 h after
drug (or placebo) administration.
I would love it if someone more knowledgeable of neuroscience explained what this meant and what the potential implications could be.
But I guess if you need to be working 14 hours/if you don't have a choice, then do what you gotta do.
If you insist on being a slave, be sure to charge at max for the finite hours you are selling, three to four times your normal rate beyond 7.5. And here is something you think you knew but don't: Young time is more precious than old time. Each hour before 35 is worth 3 hours after 35. This because experiences are new, senses are heightened, live is intense.
Take it from a retired high priest: Don't burn your life on this altar of bullshit.
For example, I make money off my own projects, I travel, I have some form of ADD, and I like to batch some of my work into 12 hour binges with the help of some medication like amphetamine.
I love my life, I don't work every day, I don't binge every day. "Work" doesn't always mean you're burning yourself on someone's pyre.
I hope you find something more fulfilling if the mere thought of 8+ hours of work must mean your are "missing the point of living".
This is a depressing comment. Can you not have new, high intensity experiences past age 35? Is losing this an inherent part of aging? Or do many just choose to avoid new experiences after a certain point?
I will also likely have acquired more financial resources and additional connections with like minded folks, which should enable interesting projects and adventures.
I'm basing this largely on how the past 5 years have gone, and the understanding I have developed during that time (from age 22 to 27). I also fully reserve the right to adjust this forecast 5 years from now :)
>implying he isn't enjoying it
I also have ADD & tried Modafinil as an alternative. My doctor prescribed me 200MG as well, and it gave me splitting headaches and, until I learned to eat first, stomach aches. My doctor suggested I try 50 MGs & 100MGs instead, which didn't give me headaches but, well, just weren't as effective for me. So I went back to the old meds.
Also, Modafinil, IME, isn't like other ADD meds. Unlike, eg, Adderall or Vyvanse, doesn't keep me awake or alert, or replace caffeine. But, obviously this varies, since modafinil is also prescribed for narcolepsy & other people here clearly have a different experience with it.
Basically, chemistry varies for each of us--and there are many variables, including metabolism, medical history, weight, what your diet is, whether & what you've eaten, and so much more. Going to the doctor is not only safer, its more efficient.
I have seen many good results with modafinil and elderly patients who are not waking up well status post stroke. It doesn't always work, especially if the stroke was huge, but there is something very heartwarming about worried family members becoming ecstatic when their loved one wakes up and people are hugging you in gratitude for prescribing it :' )
FYI, Modafininil is approved for narcolepsy. It is used sometimes for ADHD, but that is an off-label use, and it's usually not used as a first-line treatment.
You started with the premises that there was a legitimate way to fill my prescription cheaper.
And, no, buying from an unregulated pharmacy was never "worth it" to me, that's why I didn't do it even though it was an option.
I don't know what their sources were for that, and it seems likely the doctors would be very conservative in prescribing experimental drugs, so there was probably an abundance of caution in play there. That said, the long-term side effects really are not well understood at all, so I'd think twice before making a regular habit of modafinil use.
My next batch I went for 200mg's to see how that affected me. Made me super moody, fidgety and I would get agitated when something didn't go right for me straight away. 100mg seems to be the right amount for me. Everyone else I asked about 200mg said they had the same side effects.
I also don't use it much now, tending to take it once every 2 weeks to crush out some work. Wary of dependence on it, and also what it's doing to my brain.
In high school I tried caffeine to get focus, but it never worked well. This was largely caffeine from soda. After seeing a therapist and a psychiatrist, and doing a combo of stimulants for ADD + good-study/work-habit-building work suggested by the therapist, was able to get through school much more successfully than before. It gave a much clearer feeling, long-lasting (with extended release variants of the drugs) focus than soda. Really quite remarkable.
But I was never super thrilled with the tolerance building. A few days cold turkey would reset things, but I was pretty useless for those days (of the lying in bed watching TV and eating cheetos all day variety). This got harder after college, when the only available times were weekends, and I wanted to be more social. I had some concerns with some of the potential long-term health effects, too.
I managed to wean myself off, and rely on the good habits it had helped me built, but work was definitely more of a chore after that. Then I got into coffee and green tea - at first, in fairly sweet sugar+creamer or latte form. This was still sort of a jittery focus, similar to from soda. Eventually, though, I started drinking black coffee and straight green tea (no rhyme or reason to which one on a given day, just my two forms of caffeine of choice).
For me, the difference between "caffeine from straight coffee or tea" and "caffeine from heavily sweetened sugary beverage" was enormous. My jitters mostly came from the sugar levels. Couple that with more and more studies suggesting potential positive health benefits from both straight coffee and tea, and I'm feeling better overall for sure now. It's not quite the same as the magic productivity pill of amphetamines, but it's good enough for me now.
The other major thing that changed for me over the years was my interest in the material. High school and first-few-years college work can be bland, and good habits were supremely helpful here as well. Don't wait until the last minute, don't do a few 14-hour day binges to get caught up or crank something out quick and dirty, etc. Between learning that, and working my first few jobs to find roles that had more natural appeal to me, I have much less need for supplements than I used to anyway.
I take it as gelatine capsules (good quality from a serious vendor), one every day. It takes a couple of weeks before it kicks in for me, but from then on it has a distinct effect - I can think about programming problems with a lot more clarity than usual, even when tired at the end of the day. Quite weird really. Traditionally one would run a three month course, then stay off for a couple of months before starting again.
There is always the possibility of placebo effect, but I've tried a lot of things and this one feels real. There are also real scientific studies showing enhanced mental acuity from using ginseng .
Of course is has the benefit of being a natural remedy (and legal, if you care about that).
> Of course is has the benefit of being a natural remedy
Other than being non-prescription there's no benefit of it being natural. Since they're so unregulated supplement purity and potency varies significantly. Many don't contain the advertised ingredients and some are contaminated.