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Just a few off the top of my head:

  * The New Jim Crow by Michelle Alexander - changed how I think about American racism from an abstract concept to reality.  Should be required reading.

  * The Alchemist by Paulo Coelho - the book I've read more than any other, a beautiful parable about finding one's place in the world.

  * Ishmael by Daniel Quinn - although it has many flaws, this book was very effective in making me question some basic assumptions about human behavior.

  * House of Leaves by Mark Z. Danielewski - I can't exactly pin down what changed in me, but this book shook me in a way that no other book ever has.  In the right situations reading this book can be like meditation.
There are many other books that changed the way I think about literature, but I wouldn't say they affected my worldview.



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