The cure for that was pretty straightforward: Leave the damned house.
All those annoying chatty people you encounter during everyday errands? Far less annoying when you're starved for social interaction, engage them. Have interests? Turns out there are meetups for all sorts of interests. I walk into one, find a small cluster of people, and introduce myself. "Hi, I'm tbyehl, crowds of strangers are about my least favorite thing so I need to make a couple of fast friends" is quite effective.
Need more, uh, intimate social encounters? Treat yourself to a couple nice outfits, find a nice barber, and read up on /r/seduction. I'm obese and my personality is something of an acquired taste but I've hardly spent any days alone that I didn't want to.
There are +/- 72 waking hours a week that you aren't scheduled to work. That's plenty of time to build a social life that isn't dependent on commuting to a crappy office environment 5 days a week.