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A short summary would be: .NET Framework allows you to build Windows apps (desktop) and webapps; .NET Core allows you to build cross platform webapps (so, no desktop apps).

The reason is .NET Core doesn't ship with any cross platform desktop graphical class library unlike .NET Framework (ships with at least 3: Windows Forms, Windows Presentation Foundation and Universal Windows Platform).

I beg to differ. I am building a desktop/server app in .Net core right now.

What UI framework are you using for the GUI?

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