But is this technology ever going to be available to consumers? I remember reading about similar advancements almost three years ago and haven't heard anything related until now. Maybe I'm pessimistic, but I think we won't see this in practice for a Very Long Time™.
I'm guessing these "breakthroughs" have always been just around the corner. I recall having a conversation with my dentist almost 20 years ago about things that were up and coming that were about to make our lives a lot easier in terms of saving and strengthening and building tooth enamel but none of what he described ever came.
We could discover teleportation tomorrow morning and it would be twenty years before teleporters were common-place. Everything takes time to be fully realized.
If you want to know what the near future holds look at what was discovered thirty years ago.
I can appreciate this example, though in the specific context of teleportation, there'll probably be a few decades tacked on to resolve the ethical dilemmas arising from the question of whether or not the person arriving out of the other end is in fact the same person.
(I'm of the position that it doesn't matter, but still... anyway, this entire thought was just a tangent off an example)
At what point do we start being afraid to fall asleep?
I mean, cloning things has its advantages too. Could be a good idea for some people to deliberate screw up the process and drastically cut down on their daily workload. Or perhaps as a way for the less ethical to not kill or work alongside their accidental copies, but ship 'em off to join the army or something.
Teleportation going wrong can be just as exciting as prospect as it working out fine. Cloning has a lot of useful applications as well.
It presents this exact same dilemma. Up until that point I never really considered the potential ethical ramifications of teleportation.
Admittedly, the closes to teleportation I've ever felt was my first trip on a cruise ship. I went to sleep in one city, and when I opened my eyes I was suddenly in a city hundred miles away. It was magic. I also still felt like myself.
“Oh yes,” said Frankie, “but we’d have to get it out first. It’s got to be prepared.” “Treated,” said Benjy. “Diced.”
“It could always be replaced,” said Benjy reasonably, “if you think it’s important.”
“Yes, an electronic brain,” said Frankie, “a simple one would suffice.”
“A simple one!” wailed Arthur.
“Yeah,” said Zaphod with a sudden evil grin, “you’d just have to program it to say What? and I don’t understand and Where’s the tea? Who’d know the difference?”
“I’d notice the difference,” said Arthur.
“No, you wouldn’t,” said Frankie mouse, “you’d be programmed not to.”
- Hitch Hiker's Guide to the Galaxy.
Not actually about teleportation, but still apropos IMHO.
Which tells us that sentient consciousness and identity is mostly about the continuity of a signal across only some cells (nerves), and mostly rides on top of standing waves supported by those special cellular processes, at frequencies of oscillation faster than the underlying polarized/ionic chemical processes.
Then your copy claiming your job, your house, your wife and your children. Just as you would do.
Also if the transport process takes 20 lightyears, when do you send the ACQ? Will your original walk around for 20 years and then have an automated kill switch?
This sounds like a great scenario to me. I'm sure I would get along just fine with a duplicate of myself, and we could live together and get a lot more done. It sure would help a lot with avoiding burnout at work: we could take turns going to work, me one month and him the next month for instance. But two of us sharing one wife might be a bit much for her, so it'd be a lot better if we brought a second woman into the mix and lived as a polyamorous foursome (though this might be easier if we could create a teleportation clone of the wife too). It'd also be great having a double to help me on house projects, hobby projects, working on a side business, etc. And you mentioned kids: having an extra adult around the house to deal with them can only be a help, and since it's actually another me and not some other person, we're guaranteed to get along, have the same views on parenting, etc.
Honestly, I don't see any downside to this situation at all.
But I am 90% certain that if my spouse had a duplicate, they would be yelling at each other all the time.
It would be interesting to correlate answers to the question "If you had an exact duplicate, with the same body as you, the same thoughts as you, and the same memories as you up until yesterday, how would you get along?" with various aspects of psychology.
Why would your spouse be jealous of your clone? She'd now have two of you, so she's more likely to get attention when she wants it.
Who knows what will wake up from that?
There's a pun in there.
The first interval seems frozen, but I think this is Parkinson's law at work. Today's scientists and engineers have the best technology in History, and they're pursuing the boldest endeavors by that very fact.
They are a barrier to entry, and they are a measure to ensure safety of new cures. It's a tough balance.
It seems to me that the safety aspect is currently very strong, on the expense of long time-to-market and high barrier of entry to market.
That would not mean staying where we are, it would mean starting to slowly go backwards in the tools available for health care (because e.g. some antibiotics are slowly becoming inefficient and new ones should be developed - and currently the world is not doing enough of that.)
See e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095020/
Personally as someone as a kid was going up out-back Australia who's parents and care giver didn't put fluoride tablets into the water because it caused the water to `taste bad`. As a result I have screwed up teeth. Discussed this with this with my parents years later. Their reasoning for my teeth problem was poor diet and eating sugary food (Completely ignoring the fact they tossed the tablets into the bin).
Fast forward into the future with a family and two children I don't have soft drink, fruit juice in the house. Who would of known, all the kids teeth are great since our last dentist visit.
It really has to do with toothbrushing and diet. Water fluoridation is just a way to get to the people who refuse to brush their teeth.
I've also heard that early modern humans had fairly good teeth for their age despite the presumed lack of dental care, presumably also due to differences in their diet from us.
Either some leap of logic or information is missing there or you're drawing the wrong conclusion from your data
You know how dentists say "Hey, I can tell you drink a ton of soda, you need to stop"? I would get told this every time I'd go in for a cleaning, despite not drinking any soda and very little fruit juice/other sugary drinks for many years, 90%+ water only.
Fast forward 20-something years, and 2 of my daughters have had to undergo a dental rehab similar to mine at very young ages (though not quite as young as me), despite the stringent dental regimen my wife enforces to prevent this fate. There's no doubt that they got my bad teeth genes.
We're talking young kids here, ages 2-3 at the time of the operation (I was 18 mos. when I went down). They don't eat an inordinate amount of sugar, and as I stated above, my wife is very thorough with their dental hygiene. The water is fluoridated where we live. A lot of kids this age surely have much worse diets and much worse dental hygiene, but their teeth seem to be problem-free for many years.
Personally, I've had tons of fillings, 7-ish root canals, two teeth fully extracted because they were past saving, and several that badly need work and I'm not even 30 yet. Pretty much the only people living with worse teeth are opiate addicts.
I hope I win the lottery some day so I can get a mouth full of implants and be done with it. I hear the going rate for this is about $75,000.
A lot of people refuse to believe that genetics play any role, but that's absolutely not consistent with my experience, nor the opinion of most of the dentists I've had.
My parents enforced our dental care and we went to the dentist regularly when I was young. Always once a year checkup and twice a year cleaning and still I had regular dental issues.
In the second grade I can recall being brought out of class to a tooth-care specialist the school brings in to teach kids who seem uncared-for to brush their teeth. I brushed twice a day.
When I was fifteen I remember being yelled at by my dentist about how I don't look after my teeth because I had "16" cavities (the dentist, mind you, in my later years I realized was actually a bit of a hack -- all of his work fell out of my mouth and left me in terrible pain).
Around this time the dentist put me on regular fluoride mouth washes -- I went home with a bottle of some god-awful "cherry" flavoured stuff. I _still_ had repeated problems.
Fast forward to the present -- I've had one infected wisdom tooth, one infected molar -- both had to be removed. I have one half-decayed wisdom tooth that will be extracted soon. This fall I've had to have 4 fillings (some of them were put off for a while mind you).
The next year I am pending a root canal and a crown, and my dentist also has informed me that (at age 30) I require jaw surgery or I face the possibility of regular migraines due to molar wear.
I floss, brush, and use mouth wash daily. I don't eat much sugar. My parents actually raised us on a lot of raw vegetables (my mother grew, and I was raised in rural southern Ontario in Canada -- something of a agriculture belt).
The only neglect would be that my parents could not afford braces when I was young.
There has got to be some genetic aspect. Or does Hacker News as a consensus believe in shit luck?
I think I first heard about them on HN. BLIS and K12 are the keywords, if I remember correctly.
Here's an article that reviews the literature on diluted bleach rinsing: http://www.rdhmag.com/articles/print/volume-35/issue-6/colum...
It depends on the natural amount of fluorine in the water, if there's sufficient, then it's fine.
It's only in the relatively few areas where there is a deficiency that it's a problem.
And of course it also depends on diet.
Offsetting your claim are studies which show that where people exclusively drink rain water, there is a higher incidence of tooth decay.
I'm not one of those "fluoridation is a government plot to make everyone pliable" crazies. Just saying that it's far, far more important to BRUSH YOUR TEETH than to have a fluoridated water supply. Just seems to me like water fluoridation is just one of those crazy things Americans and places America has influenced do (such as using the customary measure system and circumcising their male children - sure if you dig deep enough you can justify it, but plenty of people get along just fine without it)
Cavities do not form without cariogenic bacteria, provided with a food supply of simple sugars. If you have such bacteria, there are several ways to inhibit cavity-formation, such as by chemically hardening bioapatite with fluoride ions, or by re-mineralizing tooth enamel.
Communities would be better served by mutans eradication efforts, even though they could cost far more than the $1/person-year that fluoridation costs.
If I had the cash and political backing, I would put mutans-specific bacteriophages and tricalcium phosphate in a municipal water supply. I'd then subsidize dental office visits for persons in the affected area, such that anyone desiring fluoride treatments can get them at no additional charge, and offer gratis chlorhexidine/xylitol mouth rinse after every visit.
Kill the S. mutans; end cavities.
I think the point is that fluoridation is often unnecessary because of the natural amount of fluoride in the water.
That's not really true in and of itself -- fluoridation won't fix damage done by bad hygiene or diet. As someone else mentioned, genetics and other factors all play a part too.
I'm sorry you missed out on that, teeth problems are shitty
It's actually phenomenal how little dental research has ever reached consumer behavior or dental care.
Personally I only drink RO water as tap water tastes bad to me, but I use a fluoride mouthwash (Crest) every night after brushing and flossing.
"Systemic fluorides can also give topical protection because ingested fluoride is present in saliva, which continually bathes the teeth providing a reservoir of fluoride that can be incorporated into the tooth surface to prevent decay."
It also says fluoride ingested during teeth-formation is incorporated into the teeth.
OTOH I've heard teeth are especially poor around Portland Oregon where they don't fluoride the water. I'd simply say the jury is still out.
I tend to think of iq claims specifically with a particularly large grain of salt: it's an index of society that people follow closely and is related to many, many factors.
20 years ago, all of this would sound like science fiction to me.
What one really wonders at, is technology where there were technical failures, but were really a small distance away from success for lack of combination the right bit of information to push it over the edge - but are now locked away in storage in some proprietary corner somewhere.
This one is still made of titanium though, the Zirconia ones by BioImplant seem to make more sense.
Anyway, not a cure but at least you don't need someone drilling into your head when cavities win a match.
BioImplant has a long history, with comprehensive case histories and follow-ups readily viewable on the website. This is very important for medical credibility. (I worked with the creator of BioImplant.)
On the other hand, Replicate Tooth has a very nice website!
This is happening so often, there must be a name or a law for that.
 http://www.radiolab.org/story/bringing-gamma-back (about treating Alzheimer’s disease with light)
(edit, oops the term Peter Thiel/Tyler Cowen like is "Great Stagnation." See: https://www.youtube.com/watch?v=i_yJTCDU4uE)
Parent: "Brush your teeth or you will end up with all this dental work like I have."
Kid: "Nah, we'll have regrowable teeth by then."
FWIW, I got an implant a couple of years ago and talked to my dentist about these sorts of things. On the plus side an implant is known to work, will likely last beyond my death, makes my remains easier to identify is an obliteration scenario and is available today. The down side is that you can never regrow that tooth once you've sealed a tungsten post into your jawbone.
Teeth are not perfect. If i was going to mars id have them all either crowned or replaced with implants. Teeth are strong, but not stronger than metal.
His company, Odontis, failed to bring any new thing to market, and that was 10 years ago. Perhaps now there is a more mature product.
Growing up, I never brushed and did pretty much everything a dentist advises against. I never have had a cavity. With seemingly no consequences, it was extremely hard for me to find any motivation to change my behavior. I've often wondered whether there was something genetic, and today I wonder if maybe I won some microbiome lottery.
I finally started taking care of myself due to (a) gum disease, (b) breath, and (c) yellowing of teeth, but I'm nowhere near as fastidious as some people I know who regularly get cavities and have to get all sorts of work done.
Different diets can change the flora of bacteria in a person's mouth, just as it changes the flora in a person's gut. The bacteria that produce a lot of acids generally consume simple carbohydrates, so diets rich in simple carbohydrates are correlated with the presence of cavities. Brushing and flossing prevents the simple carbohydrates from staying in the mouth for too long, which slows bacterial growth. A diet low in simple carbohydrates also inhibits bacterial growth. (It might be more accurate to say that the bacteria don't produce acids when consuming things other than simple carbohydrates --- I'm not sure.)
Mouth flora tends to be similar between members of a family. Parents pass their own flora on to their children, and over time the flora of spouses tends to become similar as well.
It's possible that your diet was conducive to good tooth health, or it's possible that you lucked out with your mouth flora, or both.
(I got a cavity a few years ago and ended up reading a bunch about tooth health. But I'm not a dentist, so there may be some inaccuracies or oversimplifications in my comment.)
Edit: I forgot to mention that some people naturally have more acidic saliva than others, which is also correlated with cavities. As far as I know, that's purely genetic.
your water might also have fluoride; when Calgary stopped fluoridating its water, i got a bunch of cavities.
Because all of that applies to me, and I've also been told that my saliva has a higher than average mineral content. I can't help but wonder if they're all related.
"Bioactive glass: Newer Sensodyne products contain calcium sodium phosphosilicate (brand name NovaMin). NovaMin sticks to an exposed dentin surface and reacts with it to form a mineralized layer. The layer formed bonds with the tooth, and is therefore strong and resistant to acid. The continuous release of calcium over time is suggested to maintain the protective effects on dentin, and provide continual occlusion of the dentin tubules. Sensodyne has removed the NovaMin ingredient from their US products"
So far I'm happy with this new toothpaste.
Any idea why? The cited articles don't appear to mention that.
IIRC, there may also have been some complexities regarding the FDA, and perhaps some cross-licensing issues, that figured into GSK's decision. The information is out there, it just requires sifting through the Google hits and piecing together the true story.
I buy European Sensodyne on Amazon for a family member with sensitive teeth, and only dug deep enough to satisfy myself that at least some EU sellers weren't scammers.
Very cool. And happy to see some numbers posted in the article to measure the success. I now understand this is very PoC, but proof none the less.
I personally hope that one day we will be able to regrow teeth. With all my crowns it's too late to repair cavities.
You just pay your taxes (or the state pays them if you can't afford it) and you're provided with healthcare.
Seems pretty reasonable if you ask me.
I wonder why they almost never linked to the source.
Like any new technology there are barriers entry erected by incumbent technology/equipment providers, but there is also a flow of new dentists and practices eager to try the latest technologies. In my visit to the dentist just now I was reminded yet again at the astonishing pace of technology change in their industry.
(Have advised early stage (IP) players in the space)
Y'all sleep through the last year?
Then one day you blink and it's gone right past you.
At things like holiday period cocktail parties I definitely heard, especially spouses, talk about how those changes would be dangerous since the surgeon wouldn't have a full picture of what was going on in the abdomen, etc. (Sometimes it's safer not to wear a seatbelt, too!)
Anyway, I think that at the same time that gallstones and kidney stones became less labor intensive there were so many new things than needed general surgeons than there was no impact on labor.
Back to your question, there seem to be stories about curing caries as a phenomenon somewhat frequently, and they've appeared regularly for decades.
Is this, instead, like developing a good cross-platform IMAP client? Anything that is good enough to replace the large email providers' own apps and web portals gets aquihired. Clearly the programmers must have been skilled enough to handle a large number of arcane edge cases and understood users well, so they'd be great people to have work for them. Plus, there's less likelihood that they continue to keep IMAP access normalized, and then also happen to provide a really effective and easy drop in encryption service.
As far as lobbyists blocking innovation to protect their industries 'status quo.' Yes I imagine it happens quite a bit. For example there is a strong lobby to keep tax forms and processes complicated and unfriendly to normal people so that companies whose bread and butter is helping you fill out your taxes each year can stay in business.
If you could prove that with a peer-reviewed paper, you'll revolutionize dentistry in the US, that's for sure. In other countries boner pills made from rhino tusks are a "hit" but that doesn't mean the FDA is corrupt for banning them as clinical treatment here.
You can still market O3 therapy as what it is, "alternative medicine." Just not clinical treatment.
If it worked, the FDA would approve it as a Class III (high risk) medical device so my guess is that the OP's friend's company either doesn't have a working product or they just don't want to put in the work to get it approved (Class III devices are the most expensive to get through the FDA).
Your buddy is exploiting vulnerable consumers in less regulated markets to sell snake oil. I wonder how many people will suffer immense pain or pick up a life threatening infection because they were convinced by conartists that oxygen was a viable alternative to proper dental care and treatment.
I see variations of this on both real and fake sites: "...the existence of FDA's ban of ozone therapy in the USA since the 1940s even after 60 years of prior successful ozone therapy in America. The FDA also ignores the fact that ozone therapy is currently used safely, effectively, and openly in Germany, Russia, and Cuba. Evidently, America's Medical Mafia is not fond of ozone therapy's proven efficacy for a wide range of diseases..."
Don't know how real this site it, but it contains much of the basic information http://www.dentaleconomics.com/articles/print/volume-99/issu...
99% of my information is from my friend; we were in graduate school together, and he worked at this medical device company at the time as a managing engineer.
It looks like the dental profession has a very serious fake news problem.
I'm looking for references to the device. It's manufactured under different brand names, so...
Company decided not to go ahead with clinical trials after doing market research on dentists in the US. Went ahead with a different drug for a different indication instead.
Now my jaw is suffers from paresthesia because of it. Most likely I will never get sensation back in that area. Spent money to become paralyzed...
I don't see the value in going to dentist for slightly less tooth pain so this sounds amazing to me.
Why? Wisdom tooth removal is still surgery, and you and your dentist should have been the ones to decide on whether it was necessary or not.
If the surgery went wrong because of other complications, that's a different issue, but you shouldn't get surgery just because other people are saying you "should".
Also, I have had terrible medical assistance my whole life, so I have to figure everything out. Not the doctors/dentists. They're just the hired help I get to do the actual heavy lifting. I honestly don't know their purpose if I have to spend half my life doing their research
Ten years ago.
A quick googling finds  which puts the maximum dose for X-rays at 0.17 mSv. Wikipedia  puts the average background radiation around the world at 3 mSv per year, or 0.082 mSv per day. So while 170 mSv is indeed "orders of magnitude more radiation" than an X-ray of a single tooth, it's still roughly in the order of magnitude I estimated (around a day's worth of background radiation).
 http://www.ada.org/en/member-center/oral-health-topics/x-ray... (section "Radiation Exposure in Dentistry")
Also, I think that you confused some units and you forgot to include link #2 ...
Also don't ever fly.
One simple recipe: cook spinach (boil, steam, microwave), wring out water, add salt and sesame oil to taste.
A cup of milk has about 300 mg.
Also, most of the calcium in the spinach is in the form of oxalates, which are not readily absorbed (and if they are absorbed, may contribute to the formation of kidney stones).
* Vitamin D3 + K2 (in its isoforms MK4 & 7) from food and synthetic
* Toothpastes with low RDA abrasion levels and without glycerine and silica
* Irrigate your teeth
* Take probiotics like Blis K12 bacteria
My dentist is thoroughly impressed with my teeth. She can still tell that I don't floss, though.
There are also chocolate and caramel chews with calcium. They aren't great either but they're alright.
Also, there's plenty of non dairy sources of calcium.
Seriously, life-hack your way out of this.
"Yeah, I know smoking is bad," he said while taking a drag on a cigarette. "But what would I do with all that free time and extra years of life?"