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Stimulants work because ADHD brains have whacked out dopamine regulation. Stimulants help smooth out the peaks and valleys associated with ADHD. Hyperfocus = overstimulated by dopamine, inattentiveness = understimulated. Taking a stimulate provides a consistent baseline level to help reduce the extremes.



Stimulants work because they activate the underperforming portions of the prefrontal cortex related to attention management.

Chalking it up to dopamine is a gross simplification.

Adderal, for example, stimulates the release / reduces the re-uptake of dopamine, norepinephrine, epinephrine, serotonin, histamine, and CART peptides.




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