I've been using Typescript, React, and mobx and absolutely in love with how they all work together. For me the high-level summary is that the vast majority of my logic is moved out of React views and into stores / controllers / whatever, with almost no boilerplate to make them play nicely together. The way its coming along reminds me of Ember quite a bit, but I get to use React and POJO's.
I definitely want to look into mobx now. Just thought I would throw out there that I've been using Nuclear-js/Immutable.js and it has a lot of the benefits you mentioned. All the data manipulation logic is encapsulated nicely, and merely appears as state to your components. You can observe memoized transforms in your components so that they only need to listen for the data they need, rather than a single change event on an entire store.
