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Build 64-bit only or release 64-bit only?

I only ask as I can usually manage 32-bit builds on dev while working, then just test there's no spooky differences when I target 64-bit.

There are issues with some projects that aren't well documented. E+C on web apps on local or remote IIS are a no-go (at least to the best of my knowledge), whereas if you can target IIS express during development it works beautifully.

I've always found that the juice has been worth the squeeze, for values of squeeze that only require me to tweak configuration for my dev box.

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