Furthermore, as (e.g.) a node developer looking to share a package with the community, I'd much maintain one package in npm than one for each of Debian, Arch, Redhat, OSX, etc.
Multiple OS package managers (choose one), and for each language/framework/... that you use, one extra. Which includes headaches for how to handle overlaps between the two. One ought to take into consideration how others are handling these issues, just to ensure you're not alone.
I do not have concrete answers, but I firmly believe that it is possible to reduce the mental and practical efforts required for package and dependency management by somehow abstracting and disciplining the current solutions.
In this context, Guile and NIX are often named. Their stated goals, however, are generally about reproducibility of builds. Could anyone point me to discussions/documentation that specifically addresses the wildfire of dependency- and package management?
Obligatory xkcd: xkcd.com/927