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There's no question. Unlike, say, ibuprofen and acetaminophen, there is no "synergy bonus".

The added pain reduction effect of acetaminophen stands in no relation to what the opioid is doing. There's no research anywhere showing that the combined effect is any more than the literal addition of taking both (for which there would be no reason if you could just as easily take a tiny bit more of the opioid that you'd be taking any way).

All it does is take away an addict's choice not to wreck their liver. And the system encourages the availability of this unnecessarily dangerous substance by awarding it a less restrictive drug schedule.

The incentives are rather twisted in this particular case.


> but it certainly has near term implications for severe abuse.

the implications being death and permanent liver damage (it's not actually stopping addicts). but looking only at the numbers, it seems to limit abuse, even in the near term. ugh.

edit 2 seeing some of the other comments, apparently it's not just this particular case. I only knew about this one

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