But screen or tmux give me persistence and re-establishing an ssh connection isn't very time consuming. A terminal multiplexer has a lot of advantages that mosh does not provide.
mosh adds another layer of terminal emulation and while the extra latency might not be a killer the terminal emulation can be as it is opaque to some features.
mosh is a great idea and sometimes useful when you are changing connections or opening and closing a laptop all day but most days I think I am better off without it.
Also I rarely have a remote connection open without forwarding some ports about so mosh often doesn't do what I need anyway.
Unfortunately every layer of terminal emulation tends to filter out some terminal capabilities. It is a small thing but I like to be able to yank a selection out of a remote vim and paste it locally and last I saw mosh's terminal emulation eats the necessary control codes.