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A few weeks ago I submitted this article https://news.ycombinator.com/item?id=10213547 about one of Peter Thiel's biotech investments and the top comment asked "How does someone very intelligent like Peter Thiel make investment decisions in an area where he lacks a huge amount of background knowledge?". I'm curious how you personally and Y Combinator as a whole goes about making investments in areas where you don't have great expertise. For example, how do you evaluate biotech markets and the YC biotech companies? How did you evaluate your energy investments?

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