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All three are great projects! As @jrochkind1 pointed out, the key difference is that OpenSeadragon is oriented around non-map imagery whereas both Leaflet and OpenLayers are focused on maps. This leads to a number of subtle (and not-so-subtle) differences.

One key point is that OpenSeadragon allows you to set the zoom level precisely where you want it without rounding to the nearest tile level. Leaflet is getting this feature (they call it fractional zoom) in 1.0, but it's not released yet and it's been missing for a long time. If you are presenting a painting, for instance, and you want the contents to fill the available space on the page, this feature is essential.

Probably the biggest difference (as far as I'm aware) is that OpenSeadragon allows you to lay out and animate hundreds of high-resolution images in the same zoomable scene. For some examples of that in action, see:


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