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My experience is that when you're on the right dosage, no. I do hit a low around 10 hours after taking the pill (I have Vyvanse), when its effects start to wear off. Other than that, the only other side effect I have is that I end up biting the inside of my lower lip, I must be sucking all the time or something. Hurts the next day.

Oh, and if you take a pill, then forget and take another, well, it leads to a VERY jittery day.

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