Mass Effect 1-3 is one of the greatest space epics of all time. Seriously, amazing.
The Last of Us is just perfect storytelling, a true last hurrah to that generation.
Uncharted is straight up living the life of Indiana Jones in modern day, in the most AMAZING set pieces ever.
Metal Gear Solid, I don't even know how to begin. From the first game to the last, the vision, the scope, the insane story, the even more insane characters. It's the alpha and the omega in storytelling, and presentation.
God of War has the most insane boss battles.
Portal is just the most unique IP, totally different than anything else.
Metroid Prime brings Metroid into 3D PERFECTLY.
Mario Galaxy, is just charming.
Regenerative medicine: understanding DNA code and restoring cells and organs, making eternal youth possible. It will take decades of hard work.
Ending cancer: We are studding virus mutations, so we could attack them without invasive techniques.
Nuclear fusion: We are simulating plasma physics. This is going to be enormous in ten years or so imho.