MacRuby allows you to write native Cocoa apps and call C/Objective-C directly without a bridge. Basically, it's an Objective-C replacement using the same runtime but a different language.
Basically, MacRuby is an MRI fork with the object system replaced by the one present in Objective-C (which is pretty similar). Integration is its main strength.
I haven't found much other than cocoa support. Which I can't get too excited about, a simple macruby app that does nothing but open up one window takes nearly 30 seconds to launch on my Core i5 macbook pro...