I use chrome with all plugins disabled unless I right-click to run them, and the only one that I regularly have to enable is the PDF viewer. I find it a much more enjoyable (and faster) browser experience and have no need for an ad blocker because flash ads are the only ones that really annoy me. I think it's a great idea to disable non-essential flash by default.
Isn't part of the point here that flash ads are mostly going to migrate to HTML5 and then having click-to-run on flash won't be blocking hardly any ads?
Disabling all plugins by default is a much better experience, especially for ads with sound. You can also opt-out the PDF viewer out of the click-to-play by visiting chrome://plugins/ and always allowing.